CYSTIC FIBROSIS - A DISORDER OF MEMBRANE TRANSPORT
A great variety of proteins have roles in moving molecules and ions across cell membranes. Passive transport proteins permit certain substances to diffuse down concentration gradients by moving through the protein's interior. Active transport proteins use ATP energy to pump substances across the membrane against their concentration gradients. To investigate the importance of transport proteins, we will consider the effects of cystic fibrosis, a genetic disorder in which there is a defect in a transport protein..
Activity
Part 1.
In this part of the activity you will visit the Cystic Fibrosis Foundation’s web site to learn about the causes and symptoms of cystic fibrosis.
Use your browser to go to http://www.cff.org/home/
Use the information provided in the “About cystic fibrosis” section to answer the following questions:
1. What are the signs and symptoms of cystic fibrosis? The signs and symptoms of cystic fibrosis are; very salty tasting skin, frequent lung infections, persistent coughing, wheezing or shortness of breath,weight gain, poor height growth, and frequent bowel movements.
2. How common is this disorder? This disorder is diagnosed 1,000 times a year, more than 70% of the diagnoses are by or before age 2. Most of the patients that have cystic fibrosis are 18 or older 45%.
3. How is cystic fibrosis diagnosed? Cystic Fibrosis is diagnosed by many ways. The most common sand accurate is the sweat test. It measures the salt in peoples sweat. There is also a blood test which is called the genetic carrier test. It detects the carriers which give CF genes to their children.
4. How is cystic fibrosis inherited? Does everyone who has a mutant gene for the protein have cystic fibrosis?Cystic fibrosis is inherited if the person gets 2 or more CTFR genes. Not everyone who has a mutant gene for cystic fibrosis has it because you have to have 2 to be diagnosed with it.
Part 2.
In this part of the activity you will read an article to learn more about cystic fibrosis.
Use your browser to go to:
http://resources.schoolscience.co.uk/MRC/3/page3.html
Use the information in this article to answer the following questions:
1. Explain the normal function of the protein that is defective in cystic fibrosis. In the beginning of figuring out cystic fibrosis they thought that there was a problem with the salt transportation. But they figured out that the outer membranes of people with cystic fibrosis are poorly preambled to chloride ions.
2. What happens to this protein in CF patients and what are the consequences for the health of these individuals? In CF patients this protein can not do the job it needs to because the chloride channel is blocked so there is no movement of chloride ions into the mucus which makes the mucus dry out because no water can move to make it moist.
Part 3.
In this part of the activity you will read about how cystic fibrosis is treated.
Use your browser to go to:
http://www.mayoclinic.com/health/cystic-fibrosis/DS00287
Use the information in the different sections of the article to answer the following questions:
1. Explain at least 3 treatments for the symptoms of cystic fibrosis. One treatment for the symptoms of cystic fibrosis is antibiotics. They help to treat and take care of lung infections. Another treatment is mucus thinning drugs. They help you to cough up the much to help with the lung functions. Oral pancreatic enzymes help the digestive tract so it can absorb nutrients correctly.
2. Discuss at least 3 ways for parents to help their children who have cystic fibrosis.3 ways that parents can help their children with cystic fibrosis are talking openly with them because emotions may run crazy, talk to other who are dealing with the situation you are and join a support group so you can get help from others or put the child in a support group if they are old enough.
A great variety of proteins have roles in moving molecules and ions across cell membranes. Passive transport proteins permit certain substances to diffuse down concentration gradients by moving through the protein's interior. Active transport proteins use ATP energy to pump substances across the membrane against their concentration gradients. To investigate the importance of transport proteins, we will consider the effects of cystic fibrosis, a genetic disorder in which there is a defect in a transport protein..
Activity
Part 1.
In this part of the activity you will visit the Cystic Fibrosis Foundation’s web site to learn about the causes and symptoms of cystic fibrosis.
Use your browser to go to http://www.cff.org/home/
Use the information provided in the “About cystic fibrosis” section to answer the following questions:
1. What are the signs and symptoms of cystic fibrosis? The signs and symptoms of cystic fibrosis are; very salty tasting skin, frequent lung infections, persistent coughing, wheezing or shortness of breath,weight gain, poor height growth, and frequent bowel movements.
2. How common is this disorder? This disorder is diagnosed 1,000 times a year, more than 70% of the diagnoses are by or before age 2. Most of the patients that have cystic fibrosis are 18 or older 45%.
3. How is cystic fibrosis diagnosed? Cystic Fibrosis is diagnosed by many ways. The most common sand accurate is the sweat test. It measures the salt in peoples sweat. There is also a blood test which is called the genetic carrier test. It detects the carriers which give CF genes to their children.
4. How is cystic fibrosis inherited? Does everyone who has a mutant gene for the protein have cystic fibrosis?Cystic fibrosis is inherited if the person gets 2 or more CTFR genes. Not everyone who has a mutant gene for cystic fibrosis has it because you have to have 2 to be diagnosed with it.
Part 2.
In this part of the activity you will read an article to learn more about cystic fibrosis.
Use your browser to go to:
http://resources.schoolscience.co.uk/MRC/3/page3.html
Use the information in this article to answer the following questions:
1. Explain the normal function of the protein that is defective in cystic fibrosis. In the beginning of figuring out cystic fibrosis they thought that there was a problem with the salt transportation. But they figured out that the outer membranes of people with cystic fibrosis are poorly preambled to chloride ions.
2. What happens to this protein in CF patients and what are the consequences for the health of these individuals? In CF patients this protein can not do the job it needs to because the chloride channel is blocked so there is no movement of chloride ions into the mucus which makes the mucus dry out because no water can move to make it moist.
Part 3.
In this part of the activity you will read about how cystic fibrosis is treated.
Use your browser to go to:
http://www.mayoclinic.com/health/cystic-fibrosis/DS00287
Use the information in the different sections of the article to answer the following questions:
1. Explain at least 3 treatments for the symptoms of cystic fibrosis. One treatment for the symptoms of cystic fibrosis is antibiotics. They help to treat and take care of lung infections. Another treatment is mucus thinning drugs. They help you to cough up the much to help with the lung functions. Oral pancreatic enzymes help the digestive tract so it can absorb nutrients correctly.
2. Discuss at least 3 ways for parents to help their children who have cystic fibrosis.3 ways that parents can help their children with cystic fibrosis are talking openly with them because emotions may run crazy, talk to other who are dealing with the situation you are and join a support group so you can get help from others or put the child in a support group if they are old enough.
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